A glimpse into the pathophysiology, mechanisms, and management of neuropathic pain

نویسندگان

  • Mohammad M Zarshenas
  • Peyman Petramfar
  • Soliman Mohammadi Samani
  • Mahmoodreza Moein
چکیده

Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Medicinal Plants Processing Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Medicinal herbs in the treatment of neuropathic pain: a review

Chronic neuropathic pain is a common significant and debilitating problem that presents a major challenge to health-care. Despite the large number of available drugs, there are no curative conventional treatments for neuropathic pain. Nowadays, more attention has been focused on the herbal formulation in the field of drug discovery. Therefore, we performed an extensive review about herbal drugs...

متن کامل

Comparison of pain behavior responses in two peripheral neuropathic models (SNI, CCI) in rat

Introduction: Peripheral nerve injury leads to neuropathic pain syndromes and different sensation like allodynia and hyperalgesia. Different animal models of neuropathic pain are used to study the neuropathic pain mechanisms. The present study was performed on two models, (SNI). The purpose of this study was comparing the behavioral responses of yhese two models and the role of saphenous and...

متن کامل

Management of Neuropathic Pain: Challenges and Opportunities

Neuropathic pain may result from a wide spectrum of insults to the peripheral or central nervous system. This may include nutritional deficiencies, systemic diseases, chemotherapy, cerebrovascular accident, surgery or trauma. The hallmark of neuropathic pain is abnormal neural activity in peripheral nerve(s) or the central nervous system. This is often accompanied by disordered sensory processi...

متن کامل

P59: Effect of Umbelliprenin on Behavioral Responses of Neuropathic Pain and the Expression of Inflammatory Factors in Chronic Constriction Injury Model of Neuropathic Pain in Male Rats

Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...

متن کامل

Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation

Objective(s): Neurotrophins (NTs) exert various effects on neuronal system. Growing evidence indicates that NTs are involved in the pathophysiology of neuropathic pain. However, the exact role of these proteins in modulating nociceptive signaling requires being defined. Thus, the aim of this study was to evaluate the effects of spinal nerve ligation (SNL) on NTs activation in the lumbar dorsal ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015